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Impact of non-pulmonary visceral metastases in the prognosis and practice of metastatic testicular germ cell tumors

Lorena Rossi, Filippo Martignano, Valentina Gallà, Antonio Maugeri, Giuseppe Schepisi
  • Lorena Rossi
    Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST)-IRCCS, Meldola (FC), Italy
  • Filippo Martignano
    Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST)-IRCCS, Meldola (FC), Italy
  • Valentina Gallà
    Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST)-IRCCS, Meldola (FC), Italy
  • Antonio Maugeri
    Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST)-IRCCS, Meldola (FC), Italy
  • Giuseppe Schepisi
    Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST)-IRCCS, Meldola (FC), Italy | giuseppe.schepisi@irst.emr.it

Abstract

Non-pulmonary visceral metastases, in bones, brain and liver, represent nearly the 10% of metastatic sites of advanced germ cell tumors and are associated with poor prognosis. This review article summarizes major evidences on the impact of different visceral sites on the prognosis, treatment and clinical outcome of patients with germ cell tumors. The clinic-biological mechanisms by which these metastatic sites are associated with poor clinical outcome remain unclear. The multimodality treatment showed a potential better survival, in particular in patients with relapsed disease. Patients with advanced germ cell tumors with visceral metastases should be referred to centers with high expertise in the clinical management of such disease.

Keywords

Testicular cancer; germ cell tumor; chemotherapy; visceral metastases.

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Submitted: 2016-02-12 11:08:27
Published: 2016-04-20 15:04:28
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Copyright (c) 2016 Lorena Rossi, Filippo Martignano, Valentina Gallà, Antonio Maugeri, Giuseppe Schepisi

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