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The role of carboplatin in the neoadjuvant chemotherapy treatment of triple negative breast cancer

Aurelio Bartolome Castrellon, Ihor Pidhorecky, Vicente Valero, Luis Estuardo Raez
  • Aurelio Bartolome Castrellon
    Breast Cancer Research, Memorial Cancer Institute, Memorial Healthcare System, Hollywood, FL, United States | acastrellon@mhs.net
  • Ihor Pidhorecky
    Surgical Oncology Services & Pancreaticobiliary Center, Memorial Cancer Institute, Memorial Healthcare System, Hollywood, FL, United States
  • Vicente Valero
    Department of Breast Medical Oncology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, United States
  • Luis Estuardo Raez
    Hematology/Oncology and Medical Director of Memorial Cancer Institute, Memorial Healthcare System, Hollywood, FL, United States

Abstract

Triple negative breast (TNBC) cancer constitutes a heterogeneous group of disease with histologic and molecular differences. Complete pathologic response to neoadjuvant chemotherapy (NACT) in TNBC is associated with improved outcomes. Efforts have been made in identifying drug combinations that will increase the response rate to preoperative chemotherapy. In this review we present recent studies that have incorporated carboplatin (Cb) in the NACT of TNBC. We discuss the homologous recombination deficiency score and the somatic or germline mutation for BRCA as potential biomarkers for future selection of patients that could benefit from the addition of Cb to NACT.

Keywords

Breast cancer; neoadjuvant chemotherapy; platinum agents.

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Submitted: 2016-11-08 23:28:05
Published: 2017-03-17 14:03:24
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Copyright (c) 2017 Aurelio Bartolome Castrellon, Ihor Pidhorecky, Vicente Valero, Luis Estuardo Raez

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