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Advances in diffuse malignant peritoneal mesothelioma

Tristan D. Yan, Raffit Hassan, Laura Welch, Paul H. Sugarbaker
  • Tristan D. Yan
    Peritoneal Surface Malignancy Program, Washington Cancer Institute, Washington Hospital Center, Washington, United States | paul.sugarbaker@medstar.net
  • Raffit Hassan
    Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institute of Health Bethesda, United States
  • Laura Welch
    Center to Protect Worker’s Rights, Silver Spring, United States
  • Paul H. Sugarbaker
    Peritoneal Surface Malignancy Program, Washington Cancer Institute, Washington Hospital Center, Washington, United States

Abstract

Malignant mesothelioma is a highly aggressive neoplasm. The incidence of malignant mesothelioma is increasing worldwide. Diffuse malignant peritoneal mesothelioma (DMPM) represents one-fourth of all mesotheliomas. Association of asbestos exposure with DMPM has been observed, especially in males. A great majority of patients present with abdominal pain and distension, caused by accumulation of tumors and ascitic fluid. In the past, DMPM was considered a pre-terminal condition; therefore attracted little attention. Patients invariably died from their disease within a year. Recently, several prospective trials have demonstrated median survival of 40 to 90 months and 5-year survival of 30% to 60% after the combined treatment using cytoreductive surgery and perioperative intraperitoneal chemotherapy. This improvement in survival has prompted new searches into the medical science related to DMPM, a disease previously ignored as uninteresting. This review article focuses on the key advances in the epidemiology, diagnosis, staging, treatments and prognosis of DMPM that have occurred in the past decade.

Keywords

Peritoneal mesothelioma - Asbestos - Cytoreductive surgery - Peritonectomy Intraperitoneal chemotherapy - Mesothelin - Doxorubicin - Cisplatin - Pemetrexed

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Submitted: 2011-12-18 11:33:42
Published: 2011-12-18 00:00:00
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Copyright (c) 2011 Tristan D. Yan, Raffit Hassan, Laura Welch, Paul H. Sugarbaker

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