Cover Image

Advances in diagnosis and treatment of malignant pleural mesothelioma

Giorgio Vittorio Scagliotti, Giovanni Selvaggi
  • Giorgio Vittorio Scagliotti
    University of Turin, Department of Clinical & Biological Sciences, Thoracic Oncology Unit, San Luigi Hospital, Regione Gonzole, 10, I-10043 Orbassano (TO); University of Turin Department of Clinical and Biological Sciences Thoracic Oncology UNIT, San Luigi Hospital Orbassano (Torino), Italy | giorgio.scagliotti@unito.it
  • Giovanni Selvaggi
    University of Turin Department of Clinical and Biological Sciences Thoracic Oncology UNIT, San Luigi Hospital Orbassano (Torino), Italy

Abstract

Malignant pleural mesothelioma (MPM) is an aggressive but relatively rare malignancy with median survival ranging from 8 to 14 months depending on stage and presentation of disease. New diagnostic procedures are urgently needed, selecting patients in earlier stages to evaluate therapeutic approaches which combine chemotherapy, surgery and radiotherapy. Combination chemotherapy represents the only resource available for advanced disease.The combination of cisplatin and pemetrexed is the treatment of choice. This review summarizes the latest developments in diagnostic techniques and the available therapeutic options for the management of MPM. Particular attention is given to the molecular basis of biologically targeted therapies to be used in the future.

Keywords

Malignant Pleural Mesothelioma - Prognostic Factors - Mesothelin - Osteopontin - Chemotherapy - Pemetrexed - Targeted Therapy - Vascular Endothelial Growth Factor - Epidermal Growth Factor

Full Text

FULL TEXT
Submitted: 2011-12-18 11:56:22
Published: 2011-12-18 00:00:00
Search for citations in Google Scholar
Related articles: Google Scholar
Abstract views:
456

Views:
FULL TEXT
115

Article Metrics

Metrics Loading ...

Metrics powered by PLOS ALM


Copyright (c) 2011 Giorgio Vittorio Scagliotti, Giovanni Selvaggi

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
 
© PAGEPress 2008-2017     -     PAGEPress is a registered trademark property of PAGEPress srl, Italy.     -     VAT: IT02125780185