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A multimodal approach to eye melanoma: patterns of care and related complications

Maria Grazia Fabrini, Federica Genovesi-Ebert, Franco Perrone, Letizia Forte, Antonella Grandinetti, Stanislao Rizzo, Luca Cionini
  • Federica Genovesi-Ebert
    Ophthalmic Surgery Division, Pisa University Hospital, Pisa, Italy
  • Franco Perrone
    Health Physics Division, Pisa University Hospital, Pisa, Italy
  • Letizia Forte
    Radiotherapy Division, Pisa University Hospital, Pisa, Italy
  • Antonella Grandinetti
    Radiotherapy Division, Pisa University Hospital, Pisa, Italy
  • Stanislao Rizzo
    Ophthalmic Surgery Division, Pisa University Hospital, Pisa, Italy
  • Luca Cionini
    Radiotherapy Division, Pisa University Hospital, Pisa, Italy

Abstract

We describe the results of multimodal treatment of uveal and conjunctival melanomas. A retrospective analysis was performed on 54 patients treated with a multimodal approach between 2003 and 2008 in a single institution. Main outcome measures were survival, enucleation rate, local tumor control, visual function preservation and complications associated with treatments. The median follow-up was 33.4 months. The 5-year overall survival was 95.3%, the local recurrence was 3.7% and the 5-year enucleation was 9.4%. Vision preservation was achieved in 84% of cases. Observed complications were cataract, retinal detachment, diplopia, glaucoma, retinopathy, optic neuropathy and scleral necrosis. A careful consideration of treatment of uveal melanoma in this study allowed us to obtain the survival rates and visual outcomes similar to previously published results, with a very small incidence of complications. the results must be interpreted in the light of recent findings on the genetic pattern of uveal melanoma.

Keywords

Melanoma - Uvea - Conjunctiva - Eye - Brachytherapy - Plaque - Bevacizumab

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Submitted: 2011-12-13 11:33:31
Published: 2011-12-14 00:00:00
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Copyright (c) 2011 Maria Grazia Fabrini, Federica Genovesi-Ebert, Franco Perrone, Letizia Forte, Antonella Grandinetti, Stanislao Rizzo, Luca Cionini

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