A multimodal approach to eye melanoma: patterns of care and related complications

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Maria Grazia Fabrini (1*), Federica Genovesi-Ebert (2), Franco Perrone (3), Letizia Forte (4), Antonella Grandinetti (5), Stanislao Rizzo (6), Luca Cionini (7)

1 Radiotherapy Division, Pisa University Hospital, Pisa, Italy.
2 Ophthalmic Surgery Division, Pisa University Hospital, Pisa, Italy.
3 Health Physics Division, Pisa University Hospital, Pisa, Italy.
4 Radiotherapy Division, Pisa University Hospital, Pisa, Italy.
5 Radiotherapy Division, Pisa University Hospital, Pisa, Italy.
6 Ophthalmic Surgery Division, Pisa University Hospital, Pisa, Italy.
7 Radiotherapy Division, Pisa University Hospital, Pisa, Italy.
(*) Corresponding Author:
Maria Grazia Fabrini
f.perrone@ao-pisa.toscana.it

Abstract

We describe the results of multimodal treatment of uveal and conjunctival melanomas. A retrospective analysis was performed on 54 patients treated with a multimodal approach between 2003 and 2008 in a single institution. Main outcome measures were survival, enucleation rate, local tumor control, visual function preservation and complications associated with treatments. The median follow-up was 33.4 months. The 5-year overall survival was 95.3%, the local recurrence was 3.7% and the 5-year enucleation was 9.4%. Vision preservation was achieved in 84% of cases. Observed complications were cataract, retinal detachment, diplopia, glaucoma, retinopathy, optic neuropathy and scleral necrosis. A careful consideration of treatment of uveal melanoma in this study allowed us to obtain the survival rates and visual outcomes similar to previously published results, with a very small incidence of complications. the results must be interpreted in the light of recent findings on the genetic pattern of uveal melanoma.

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How to Cite
Fabrini, M. G., Genovesi-Ebert, F., Perrone, F., Forte, L., Grandinetti, A., Rizzo, S., & Cionini, L. (2011). A multimodal approach to eye melanoma: patterns of care and related complications. Oncology Reviews, 3(1), 41-49. https://doi.org/10.4081/oncol.2009.41