Cover Image

Evaluation of metastatic potential of prostate cancer

Yoshitomo Chihara, Hiroki Kuniyasu, Kiyohide Fujimoto, Yoshihiko Hirao
  • Yoshitomo Chihara
    Department of Molecular Pathology, Nara Medical University School of Medicine, Japan | cooninh@zb4.so-net.ne.jp
  • Hiroki Kuniyasu
    Department of Molecular Pathology, Nara Medical University School of Medicine, Japan
  • Kiyohide Fujimoto
    Department of Urology, Nara Medical University, Japan
  • Yoshihiko Hirao
    Department of Urology, Nara Medical University, Japan

Abstract

We aimed to establish a method for evaluating malignant potential of prostate cancer using prostatic core needle biopsy (PCNB) before prostatectomy. If we can know the final pathological stage before treatment, we can select the most suitable therapeutic tactics. We then examined the expression of E-cadherin and type IV collagenase (MMP-9/-2), which play essential role in cancer cell invasion and metastasis. The expression ratio of MMP-9/-2 to E-cadherin (MER) is revealed as the relevant marker correlated with the final pathological stage and Gleason score by prostatectomy specimens. We next confirmed the significance of MER in PCNB, which means PCNB MER enables the prediction of the final pathologic stage at the cancer diagnosis. However, the methodology measuring MER is complicated to produce an observer-to-observer deviation. We then establish a bicolor fluorescent ISH (bicolor FISH) with a computerized fluorescence detector- based system. By this method, we can reduce an observer-to-observer deviation and a slide-to-slide deviation. The bicolor FISH-based MER is a useful tool for the preoperative evaluation of the final pathologic stage, by which we can assure a decision of prostatectomy indication.

Keywords

Prostate cancer - E-cadherin - Matrix metalloproteinase - VEGF - Invasion - Metastasis

Full Text

FULL TEXT
Submitted: 2011-11-30 12:12:34
Published: 2011-06-30 00:00:00
Search for citations in Google Scholar
Related articles: Google Scholar
Abstract views:
513

Views:
FULL TEXT
179

Article Metrics

Metrics Loading ...

Metrics powered by PLOS ALM


Copyright (c) 2011 Yoshitomo Chihara, Hiroki Kuniyasu, Kiyohide Fujimoto, Yoshihiko Hirao

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
 
© PAGEPress 2008-2017     -     PAGEPress is a registered trademark property of PAGEPress srl, Italy.     -     VAT: IT02125780185