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Hepatitis C virus and non-Hodgkin’s lymphoma: biology, epidemiology and therapy

Gabriele Pozzato, Francesca Zorat, Stefania Bonetto, Cesare Mazzaro
  • Gabriele Pozzato
    Dipartimento Clinico di Scienze Mediche, Tecnologiche e Traslazionali, University of Trieste Unita` Operativa Seconda Medicina/Ematologia, Ospedale Maggiore, Trieste, Italy | g.pozzato@fmc.units.it
  • Francesca Zorat
    Dipartimento Clinico di Scienze Mediche, Tecnologiche e Traslazionali, University of Trieste, Italy
  • Stefania Bonetto
    Dipartimento Clinico di Scienze Mediche, Tecnologiche e Traslazionali, University of Trieste, Italy
  • Cesare Mazzaro
    Secondo Dipartimento di Medicina, Pordenone General Hospital, Pordenone, Italy

Abstract

Although the association between the hepatitis C virus and B-cell non-Hodgkin’s lymphomas is still controversial, there is increasing evidence of the role of this virus in several B-cell lymphoproliferative disorders, whose prototype is mixed cryoglobulinemia. The aim of the present paper was to provide an overview of the biological mechanisms involved in the development of B-cell disorders in the course of chronic hepatitis C virus infection. The link between this virus and non-Hodgkin’s lymphomas is also considered from an epidemiological point of view, and the great regional differences in the prevalence of hepatitis C-associated lymphomas are discussed. Finally, the role of antiviral therapy and suggestions about the most appropriate, currently available, therapeutic approaches are also discussed.

Keywords

Hepatitis C virus - Mixed cryoglobulinemia - Non-Hodgkin’s lymphoma - Interferon - Ribavirin

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Submitted: 2011-12-05 10:17:41
Published: 2011-11-30 00:00:00
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Copyright (c) 2011 Gabriele Pozzato, Francesca Zorat, Stefania Bonetto, Cesare Mazzaro

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