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Chemotherapy and target therapy as neo-adjuvant approach for initially unresectable colorectal liver metastases

Luigi Rossi, Angelo Zullo, Federica Zoratto, Anselmo Papa, Martina Strudel, Maria Colonna, Silverio Tomao
  • Luigi Rossi
    Department of Medico-Surgical Sciences and Biotechnologies, Oncology Unit, S.M. Goretti Hospital, Latina – “Sapienza” University of Rome, Italy
  • Angelo Zullo
    Gastroenterology and Digestive Endoscopy; Nuovo Regina Margherita Hospital, Rome, Italy
  • Federica Zoratto
    Department of Medico-Surgical Sciences and Biotechnologies, Oncology Unit, S.M. Goretti Hospital, Latina – “Sapienza” University of Rome, Italy
  • Anselmo Papa
    Department of Medico-Surgical Sciences and Biotechnologies, Oncology Unit, S.M. Goretti Hospital, Latina – “Sapienza” University of Rome, Italy
  • Martina Strudel
    Department of Medico-Surgical Sciences and Biotechnologies, Oncology Unit, S.M. Goretti Hospital, Latina – “Sapienza” University of Rome, Italy
  • Maria Colonna
    Affiliation not present
  • Silverio Tomao
    Department of Medico-Surgical Sciences and Biotechnologies, Oncology Unit, S.M. Goretti Hospital, Latina – “Sapienza” University of Rome, Italy | silverio.tomao@uniroma1.it

Abstract

Although surgery is the most effective treatment for liver metastases in colorectal cancer patients, only 15-20% of these patients are suitable for a radical surgical approach, and metastases recurrence may occur at follow up. In the last decade, the use of pre-operative chemotherapy in combination with new biological drugs has been introduced. We reviewed data of neo-adjuvant chemotherapy strategies aimed at increasing the resection rate of liver metastases in colorectal cancer patients who were initially considered unresectable.

Keywords

liver metastasis, colorectal cancer, chemotherapy, neo-adjuvant chemotherapy, biological therapy, bevacizumab, cetuximab.

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Submitted: 2012-02-28 16:02:25
Published: 2012-06-14 18:44:59
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Copyright (c) 2012 Luigi Rossi, Angelo Zullo, Federica Zoratto, Anselmo Papa, Martina Strudel, Maria Colonna, Silverio Tomao

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