Advances in diffuse malignant peritoneal mesothelioma

  • Tristan D. Yan | paul.sugarbaker@medstar.net Peritoneal Surface Malignancy Program, Washington Cancer Institute, Washington Hospital Center, Washington, United States.
  • Raffit Hassan Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institute of Health Bethesda, United States.
  • Laura Welch Center to Protect Worker’s Rights, Silver Spring, United States.
  • Paul H. Sugarbaker Peritoneal Surface Malignancy Program, Washington Cancer Institute, Washington Hospital Center, Washington, United States.

Abstract

Malignant mesothelioma is a highly aggressive neoplasm. The incidence of malignant mesothelioma is increasing worldwide. Diffuse malignant peritoneal mesothelioma (DMPM) represents one-fourth of all mesotheliomas. Association of asbestos exposure with DMPM has been observed, especially in males. A great majority of patients present with abdominal pain and distension, caused by accumulation of tumors and ascitic fluid. In the past, DMPM was considered a pre-terminal condition; therefore attracted little attention. Patients invariably died from their disease within a year. Recently, several prospective trials have demonstrated median survival of 40 to 90 months and 5-year survival of 30% to 60% after the combined treatment using cytoreductive surgery and perioperative intraperitoneal chemotherapy. This improvement in survival has prompted new searches into the medical science related to DMPM, a disease previously ignored as uninteresting. This review article focuses on the key advances in the epidemiology, diagnosis, staging, treatments and prognosis of DMPM that have occurred in the past decade.

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Published
2011-12-18
Section
Reviews
Keywords:
Peritoneal mesothelioma - Asbestos - Cytoreductive surgery - Peritonectomy Intraperitoneal chemotherapy - Mesothelin - Doxorubicin - Cisplatin - Pemetrexed
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How to Cite
Yan, T. D., Hassan, R., Welch, L., & Sugarbaker, P. H. (2011). Advances in diffuse malignant peritoneal mesothelioma. Oncology Reviews, 1(1), 53-64. Retrieved from https://oncologyreviews.org/index.php/or/article/view/oncol.2007.53