Splice variants of androgen receptor and prostate cancer

  • Orazio Caffo | orazio.caffo@apss.tn.it Medical Oncology Department, Santa Chiara Hospital, Trento, Italy.
  • Francesca Maines Medical Oncology Department, Santa Chiara Hospital, Trento, Italy.
  • Antonello Veccia Medical Oncology Department, Santa Chiara Hospital, Trento, Italy.
  • Stefania Kinspergher Medical Oncology Department, Santa Chiara Hospital, Trento, Italy.
  • Enzo Galligioni Medical Oncology Department, Santa Chiara Hospital, Trento, Italy.

Abstract

Over the last ten years, two new-generation hormonal drugs and two chemotherapeutic agents have been approved for the treatment of metastatic castration-resistant prostate cancer. Unfortunately, some patients have primary resistance to them and the others eventually develop secondary resistance. It has recently been suggested that the presence of androgen receptor splice variants plays a leading role in the primary and secondary resistance to the new hormonal drugs, whereas their presence seem to have only a partial effect on the activity of the chemotherapeutic agents. The aim of this paper is to review the published data concerning the role of androgen receptor splice variants in prostate cancer biology, and their potential use as biomarkers when making therapeutic decisions.

Downloads

Download data is not yet available.
Published
2016-05-30
Section
Reviews
Keywords:
Prostate cancer, splice variants, enzalutamide, abiraterone, cabazitaxel.
Statistics
Abstract views: 1628

PDF: 841
HTML: 536
Share it

PlumX Metrics

PlumX Metrics provide insights into the ways people interact with individual pieces of research output (articles, conference proceedings, book chapters, and many more) in the online environment. Examples include, when research is mentioned in the news or is tweeted about. Collectively known as PlumX Metrics, these metrics are divided into five categories to help make sense of the huge amounts of data involved and to enable analysis by comparing like with like.

How to Cite
Caffo, O., Maines, F., Veccia, A., Kinspergher, S., & Galligioni, E. (2016). Splice variants of androgen receptor and prostate cancer. Oncology Reviews, 10(1). https://doi.org/10.4081/oncol.2016.297