CDK4/6 inhibitors in advanced breast cancer, what is beyond?

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Amrallah A. Mohammed *
Hanaa Rashied
Fifi Mostafa Elsayed
(*) Corresponding Author:
Amrallah A. Mohammed | amrallaabdelmoneem@yahoo.com

Abstract

Resistant to hormonal treatment considered the main clinical challenge in the management of advanced breast cancer (ABC). The use of CDK4/6 inhibitors (CDK4/6I) may change the treatment landscape. In this mandated review, we will focus on the applicable role of CDK4/6I in the management of HR+/HER2- ABC, mechanisms of resistance, and promising future implementation.


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