The biological mechanism involved in anticancer properties of amniotic membrane

  • Ameneh Jafari Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Proteomics Research Center, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran, Islamic Republic of.
  • Hassan Niknejad Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran, Islamic Republic of.
  • Mostafa Rezaei-Tavirani Proteomics Research Center, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran, Islamic Republic of.
  • Hakimeh Zali | h.zali@sbmu.ac.ir Proteomics Research Center, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran; Nanotechnology and Tissue Engineering Research Center, School of Advanced Technologies in Medicine, ShahidBeheshti University of Medical Sciences, Tehran, Iran, Islamic Republic of.
  • Caitlin D’Amico University of Vermont Medical Center, Burlington, VT, United States.

Abstract

The main role of amniotic membrane (AM), or amnion, is to protect the fetus from drying out and create an appropriate environment for its growth. AM is also a suitable candidate for the treatment of various diseases due to its unique characteristics. In recent years, a new line of research has focused on the anticancer properties of amnion and its potential use in cancer treatment. The in vitro and in vivo studies indicate the anti-proliferative and proapoptotic activities, as well as the angioregulatory and immunomodulatory properties of the amniotic membrane. However, the exact mechanism and molecular basis of these anticancer effects of AM are not fully elucidated. This paper presents an overview of the latest findings and knowledge about the anticancer effects of AM and its underlying molecular mechanisms, which is crucial for the application of amnion in cancer therapy.

Downloads

Download data is not yet available.
Published
2020-02-18
Section
Reviews
Keywords:
Amniotic membrane, cancer, apoptosis, angiogenesis.
Statistics
Abstract views: 281

PDF: 160
HTML: 15
Share it

PlumX Metrics

PlumX Metrics provide insights into the ways people interact with individual pieces of research output (articles, conference proceedings, book chapters, and many more) in the online environment. Examples include, when research is mentioned in the news or is tweeted about. Collectively known as PlumX Metrics, these metrics are divided into five categories to help make sense of the huge amounts of data involved and to enable analysis by comparing like with like.

How to Cite
Jafari, A., Niknejad, H., Rezaei-Tavirani, M., Zali, H., & D’Amico, C. (2020). The biological mechanism involved in anticancer properties of amniotic membrane. Oncology Reviews, 14(1). https://doi.org/10.4081/oncol.2020.429