Renal toxicity with mammalian target of rapamycin inhibitors: A meta-analysis of randomized clinical trials

a meta-analysis of randomized clinical trials

  • Ravi K. Paluri | rpaluri@uabmc.edu Division of Hematology-Oncology, Department of Medicine, University of Alabama at Birmingham, AL, United States.
  • Guru Sonpavde Section of Medical Oncology, Department of Medicine, Dana-Farber Cancer Institute, Harvard Medical School, MA, United States.
  • Charity Morgan Department of Biostatistics, University of Alabama at Birmingham, AL, United States.
  • Jacob Rojymon Department of Radiation Oncology, University of Alabama at Birmingham, AL, United States.
  • Anastasia Hartzes Mar Department of Biostatistics, University of Alabama at Birmingham, AL, United States.
  • Radhika Gangaraju Division of Hematology-Oncology, Department of Medicine, University of Alabama at Birmingham, AL, United States.

Abstract

A meta-analysis of randomized clinical trials (RCT) was done to determine the relative risk (RR) of acute kidney injury (AKI) with the use of mammalian target of rapamycin (mTOR) inhibitors. Citations from PubMed/Medline, clinical trials.gov, package inserts and abstracts from major conferences were reviewed to include RCTs comparing arms with or without mTOR inhibitors. The RR of all grade AKI in patients taking mTOR inhibitors compared to patients not on mTOR inhibitors was 1.55 (95% CI: 1.11 to 2.16, P=0.010). There was no significant difference in the risk of high-grade AKI for the two groups (RR=1.29, P=0.118, 95% CI: 0.94 to 1.77). There was no significant difference in the incidence rates for either all grade or high-grade AKI between the two groups. There was no publication bias and the trials were of high quality per Jadad scoring.

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Published
2019-11-25
Section
Reviews
Keywords:
Mammalian target of rapamycin inhibitors, temsirolimus, everolimus, acute kidney injury, renal toxicity, meta-analysis.
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How to Cite
Paluri, R. K., Sonpavde, G., Morgan, C., Rojymon, J., Hartzes Mar, A., & Gangaraju, R. (2019). Renal toxicity with mammalian target of rapamycin inhibitors: A meta-analysis of randomized clinical trials. Oncology Reviews, 13(2). https://doi.org/10.4081/oncol.2019.455