Role of CD1A and HSP60 in the antitumoral response of oesophageal cancer

  • Simona Corrao | francapp@hotmail.com Dipartimento di Medicina Sperimentale, Sezione di Anatomia Umana, Università di Palermo, Palermo, Italy.
  • Giampiero La Rocca Dipartimento di Medicina Sperimentale, Sezione di Anatomia Umana, Università di Palermo, Palermo, Italy.
  • Rita Anzalone Dipartimento di Medicina Sperimentale, Sezione di Anatomia Umana, Università di Palermo, Palermo, Italy.
  • Lorenzo Marasà Dipartimento di Medicina Sperimentale, Sezione di Anatomia Umana, Università di Palermo, Palermo, Italy.
  • Felicia Farina Dipartimento di Medicina Sperimentale, Sezione di Anatomia Umana, Università di Palermo, Palermo, Italy.
  • Giovanni Zummo Dipartimento di Medicina Sperimentale, Sezione di Anatomia Umana, Università di Palermo, Palermo, Italy.
  • Francesco Cappello Dipartimento di Medicina Sperimentale, Sezione di Anatomia Umana, Università di Palermo, Palermo, Italy.

Abstract

Oesophageal cancer (OC) is one of the most common and severe forms of tumor. A wider knowledge of molecular mechanisms which lead to a normal epithelium becoming a neoplasm may reveal new strategies to improve treatment and outcome of this disease. In this review, we report recent findings concerning molecular events which take place during carcinogenesis of the oesophagus. In particular, we focus on the role of two molecules, CD1a and Hsp60, which are overexpressed in oesophageal and many other types of tumor. Both molecules may present tumor antigens and promote in situ the stimulation of an antitumoral immune activity. We suggest there is a synergistic action between these molecules. Further knowledge about their intracellular pathways and extracellular roles may help develop new antitumoral tools for OC.

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Published
2011-12-19
Section
Reviews
Keywords:
Immune response - Dendritic cells - Chaperonopathies - Chaperonotherapy
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How to Cite
Corrao, S., La Rocca, G., Anzalone, R., Marasà, L., Farina, F., Zummo, G., & Cappello, F. (2011). Role of CD1A and HSP60 in the antitumoral response of oesophageal cancer. Oncology Reviews, 1(4), 225-232. Retrieved from https://oncologyreviews.org/index.php/or/article/view/oncol.2007.225