The role of vitamin D in breast cancer

  • Tu Tu Aung | dohmta@msu.edu Division of Hematology/Oncology, Department of Medicine, Michigan State University, East Lansing, United States.
  • Sreenivasa R. Chandana Division of Hematology/Oncology, Department of Medicine, Michigan State University, East Lansing, United States.
  • Karl J. D’Silva Division of Hematology/Oncology, Department of Medicine, Michigan State University, East Lansing, United States.
  • Nikolay V. Dimitrov Division of Hematology/Oncology, Department of Medicine, Michigan State University, East Lansing, United States.

Abstract

The biological role of vitamin D outside of calcium homeostasis is still under evaluation. The ability of vitamin D to inhibit cell proliferation and induce differentiation makes it a potential modifier of neoplastic transformation. Vitamin D affects the cell cycle, apoptosis, hormone receptors, angiogenesis, and hypoxia, all of which are related to the breast cancer growth, progression and metastasis. A large percentage of the industrial-world population is deficient in vitamin D. Epidemiological evidence suggests that vitamin D deficiency increases the risk of breast cancer. Vitamin D may have synergistic, additive, or antagonistic effects when combined with other therapeutic agents against breast cancer. Vitamin D appears to depress aromatase inhibitor by acting through cytochrome P 450. This evidence along with pre-clinical and clinical studies, justify the inclusion of vitamin D in future clinical trials related to breast cancer in order to determine its efficacy as a part of the breast cancer therapeutic armament.

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Published
2011-12-14
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Issue
Section
Reviews
Keywords:
Vitamin D - Breast cancer - Carcinogenesis - Prevention - Treatment
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How to Cite
Aung, T. T., Chandana, S. R., D’Silva, K. J., & Dimitrov, N. V. (2011). The role of vitamin D in breast cancer. Oncology Reviews, 3(1), 19-25. https://doi.org/10.4081/oncol.2009.19