Micro-ribonucleic acid and carcinogenesis: breast cancer as an example

  • Manal Al-Khanbashi Medical Oncology Unit, Department of Medicine, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Oman.
  • Mansour Al-Moundhri | mansours@squ.edu.om Medical Oncology Unit, Department of Medicine, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Oman.

Abstract

MicroRNAs (miRNAs) are a class of small non-coding RNAs that have unique functions at post-transcriptional level (epigenetics). MiRNAs play a pivotal role in controlling gene expression at various levels including differentiation, cell-cycle regulation, apoptosis and many others in mammals as well as in many organisms. Recently, there has been greater understanding of the contribution of dysregulation of miRNA into disease status in particular carcinogenesis. In this review, we will discuss miRNA discovery, nomenclature, function, contribution of their dysregulation into disease status in particular carcinogenesis and their potential role as biomarkers.

Dimensions

Altmetric

PlumX Metrics

Downloads

Download data is not yet available.
Published
2015-10-02
Info
Issue
Section
Reviews
Keywords:
miRNA, breast cancer, neo-adjuvant chemotherapy.
Statistics
  • Abstract views: 1912

  • PDF: 833
  • HTML: 1130
How to Cite
Al-Khanbashi, M., & Al-Moundhri, M. (2015). Micro-ribonucleic acid and carcinogenesis: breast cancer as an example. Oncology Reviews, 9(1). https://doi.org/10.4081/oncol.2015.279