An updated review of cribriform carcinomas with emphasis on histopathological diagnosis and prognostic significance

  • Giovanni Branca | giobranca81@gmail.com Department of Human Pathology G. Barresi, University of Messina, Italy.
  • Antonio Ieni Department of Human Pathology G. Barresi, University of Messina, Italy.
  • Valeria Barresi Department of Human Pathology G. Barresi, University of Messina, Italy.
  • Giovanni Tuccari Department of Human Pathology G. Barresi, University of Messina, Italy.
  • Rosario Alberto Caruso Department of Human Pathology G. Barresi, University of Messina, Italy.

Abstract

Cribriform is a histopathological term used to describe a neoplastic epithelial proliferation in the form of large nests perforated by many quite rounded different-sized spaces. This growth pattern may be seen in carcinomas arising in different organs, and shows important prognostic implications. Therefore, recent data in literature suggest that cribriform carcinoma is a histologically and clinically distinctive type of tumour that should be separated from other similar tumour types. In this article, the pathology of cribriform adenocarcinoma of the prostate, lung, breast, stomach, colon, thyroid, and skin is discussed with particular reference to morphologic and immunohistochemical features, differential diagnosis, and clinical behaviour.

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Published
2017-03-10
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Section
Reviews
Keywords:
Cribriform carcinoma, histopathology, immunohistochemistry, differential diagnosis, prognosis.
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How to Cite
Branca, G., Ieni, A., Barresi, V., Tuccari, G., & Caruso, R. A. (2017). An updated review of cribriform carcinomas with emphasis on histopathological diagnosis and prognostic significance. Oncology Reviews, 11(1). https://doi.org/10.4081/oncol.2017.317