Role of membrane-embedded drug efflux ABC transporters in the cancer chemotherapy

  • Sonu Kumar Gupta Department of Biochemistry, School of Basic and Applied Sciences, Central University of Punjab, Punjab, India.
  • Priyanka Singh Department of Biochemistry, School of Basic and Applied Sciences, Central University of Punjab, Punjab, India.
  • Villayat Ali Department of Biochemistry, School of Basic and Applied Sciences, Central University of Punjab, Punjab, India.
  • Malkhey Verma | malkhey@yahoo.com Department of Biochemistry, School of Basic and Applied Sciences, Central University of Punjab, Punjab, India.

Abstract

One of the major problems being faced by researchers and clinicians in leukemic treatment is the development of multidrug resistance (MDR) which restrict the action of several tyrosine kinase inhibitors (TKIs). MDR is a major obstacle to the success of cancer chemotherapy. The mechanism of MDR involves active drug efflux transport of ABC superfamily of proteins such as Pglycoprotein (P-gp/ABCB1), multidrug resistance-associated protein 2 (MRP2/ABCC2), and breast cancer resistance protein (BCRP/ABCG2) that weaken the effectiveness of chemotherapeutics and negative impact on the future of anticancer therapy. In this review, the authors aim to provide an overview of various multidrug resistance (MDR) mechanisms observed in cancer cells as well as the various strategies developed to overcome these MDR. Extensive studies have been carried out since last several years to enhance the efficacy of chemotherapy by defeating these MDR mechanisms with the use of novel anticancer drugs that could escape from the efflux reaction, MDR modulators or chemosensitizers, multifunctional nanotechnology, and RNA interference (RNAi) therapy.

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Published
2020-07-06
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Section
Reviews
Keywords:
ABC transporter, breast cancer resistance protein (BCRP), chronic myeloid leukemia (CML), multidrug resistance (MDR), P-glycoprotein.
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How to Cite
Gupta, S. K., Singh, P., Ali, V., & Verma, M. (2020). Role of membrane-embedded drug efflux ABC transporters in the cancer chemotherapy. Oncology Reviews, 14(2). https://doi.org/10.4081/oncol.2020.448