Apoptosis and genes involved in oral cancer - a comprehensive review

  • Ruby Dwivedi DHR-MRU and Department of Oral and Maxillofacial Surgery, Faculty of Dental Sciences, King George’s Medical University, Lucknow, Uttar Pradesh, India.
  • Rahul Pandey | pandey.rahul.dr@gmail.com DHR-MRU and Department of Oral and Maxillofacial Surgery, Faculty of Dental Sciences, King George’s Medical University, Lucknow, Uttar Pradesh, India.
  • Shaleen Chandra DHR-MRU and Department of Oral and Maxillofacial Surgery, Faculty of Dental Sciences, King George’s Medical University, Lucknow, Uttar Pradesh, India.
  • Divya Mehrotra DHR-MRU and Department of Oral and Maxillofacial Surgery, Faculty of Dental Sciences, King George’s Medical University, Lucknow, Uttar Pradesh, India.

Abstract

Oral cancers needs relentless research due to high mortality and morbidity associated with it. Despite of the comparable ease in accessibility to these sites, more than 2/3rd cases are diagnosed in advanced stages. Molecular/genetic studies augment clinical assessment, classification and prediction of malignant potential of oral lesions, thereby reducing its incidence and increasing the scope for early diagnosis and treatment of oral cancers. Herein we aim to review the role of apoptosis and genes associated with it in oral cancer development in order to aid in early diagnosis, prediction of malignant potential and evaluation of possible treatment targets in oral cancer. An internet-based search was done with key words apoptosis, genes, mutations, targets and analysis to extract 72 articles after considering inclusion and exclusion criteria. The knowledge of genetics and genomics of oral cancer is of utmost need in order to stop the rising prevalence of oral cancer. Translational approach and interventions at the early stage of oral cancer, targeted destruction of cancerous cells by silencing or promoting involved genes should be the ideal intervention.

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Published
2020-07-09
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Section
Reviews
Keywords:
Apoptosis, genes, mutations, oral cancer, target.
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How to Cite
Dwivedi, R., Pandey, R., Chandra, S., & Mehrotra, D. (2020). Apoptosis and genes involved in oral cancer - a comprehensive review. Oncology Reviews, 14(2). https://doi.org/10.4081/oncol.2020.472