Clinical and pathological implications of GSTM1 and GSTT1 gene deletions in sporadic breast cancer

  • Cassio Cardoso Filho | salete@caism.unicamp.br Department of Obstetrics and Gynecology, School of Medicine, Universidade Estadual de Campinas UNICAMP, Brazil.
  • Gustavo Lourenço Laboratory of Conventional and Molecular Cytogenetics Blood Center/UNICAMP, Brazil.
  • Julia Yoriko Shinzato Department of Obstetrics and Gynecology, School of Medicine, Universidade Estadual de Campinas UNICAMP, Brazil.
  • Luiz Carlos Zeferino Department of Obstetrics and Gynecology, School of Medicine, Universidade Estadual de Campinas UNICAMP, Brazil.
  • Fernando Ferreira Costa Department of Clinical Medicine FCM/UNICAMP, Brazil.
  • Carmen Silvia Passos Lima Department of Clinical Medicine FCM/UNICAMP, Brazil.
  • Maria Salete Costa Gurgel Cidade Universitária Zeferino Vaz Barão Geraldo, Campinas, Brazil.

Abstract

There is a lack of consensus about the influence of GST M1/T1 gene deletions (DEL) on sporadic breast cancer (SBC). To evaluate the occurrence of DEL in 177 SBC cases and in 169 controls, and compare clinical and biological characteristics. A lower frequency of GSTM1 DEL was observed in mulatto women, OR=0.48 (0.24–0.98). The risk of nuclear grade 3 tumors (GN3) was lower in patients with GSTT1 DEL, OR=0.37 (0.15–0.90). DEL of at least one gene (ALOG) was associated with women who had not breastfed, OR=0.41 (0.19–0.88), and with negative hormone receptor, HR–, ORadj=2.25 (1.03–4.90). Both genes deleted (BGD) was associated with non-classic invasive ductal carcinoma (NCDC), ORadj=12.09 (1.03–142.03). Mulatto women with SBC had a lower frequency of GSTM1 DEL, while tumors differentiated were related to GSTT1 DEL. HRtumors were related with DEL ALOG, and the BGD was associated with a greater risk of NCDC.

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Published
2011-12-14
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Issue
Section
Reviews
Keywords:
Breast cancer - Genetic polymorphisms - Glutathione S-transferase - GSTM1 - GSTT1
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How to Cite
Cardoso Filho, C., Lourenço, G., Shinzato, J. Y., Zeferino, L. C., Ferreira Costa, F., Passos Lima, C. S., & Costa Gurgel, M. S. (2011). Clinical and pathological implications of GSTM1 and GSTT1 gene deletions in sporadic breast cancer. Oncology Reviews, 2(1), 36-43. https://doi.org/10.4081/oncol.2008.107