The role of molecular strategies in the evaluation of surgical margins in oropharyngeal squamous cell carcinoma

  • Anastasios N. Kanatas | a.kanatas@doctors.org.uk Oral and Maxillofacial Department, Leeds Dental Institute, The Worsley Building, Leeds, United Kingdom.
  • Andrew T. Harris Oral Biology, University of Leeds, Leeds, .
  • Michael Messenger Tissue Engineering Research, Department of Oral Biology, Leeds Dental Institute, Leeds, United Kingdom.
  • David Houghton Oral and Facial Specialties Department, Pinderfields General Hospital, Wakefield, United Kingdom.
  • Simon N. Rogers Regional Maxillofacial Unit, Faculty of Health, Edge Hill University, University Hospital Aintree, Liverpool, .

Abstract

The recurrence of a tumour at the resection margins in head and neck squamous cell carcinoma (HNSCC) has profound implications on the morbidity and mortality of the patient. At present HNSCC does not undergo any form of molecular analysis to aid treatment strategy and prognosticate for those individuals at higher risk of recurrence. This article aims to review current research into molecular strategies for tumour evaluation, highlighting conflicting evidence and possible novel concepts for further exploration.

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Published
2011-12-14
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Issue
Section
Reviews
Keywords:
Head and neck cancer - Epigenetics - Spectroscopy - Surgical margins - Oral and maxillofacial cancer
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  • FULL TEXT: 159
How to Cite
Kanatas, A. N., Harris, A. T., Messenger, M., Houghton, D., & Rogers, S. N. (2011). The role of molecular strategies in the evaluation of surgical margins in oropharyngeal squamous cell carcinoma. Oncology Reviews, 3(3), 161-167. https://doi.org/10.4081/oncol.2009.90

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