Hepatitis C virus and non-Hodgkin’s lymphoma: biology, epidemiology and therapy

  • Gabriele Pozzato | g.pozzato@fmc.units.it Dipartimento Clinico di Scienze Mediche, Tecnologiche e Traslazionali, University of Trieste Unita` Operativa Seconda Medicina/Ematologia, Ospedale Maggiore, Trieste, Italy.
  • Francesca Zorat Dipartimento Clinico di Scienze Mediche, Tecnologiche e Traslazionali, University of Trieste, Italy.
  • Stefania Bonetto Dipartimento Clinico di Scienze Mediche, Tecnologiche e Traslazionali, University of Trieste, Italy.
  • Cesare Mazzaro Secondo Dipartimento di Medicina, Pordenone General Hospital, Pordenone, Italy.

Abstract

Although the association between the hepatitis C virus and B-cell non-Hodgkin’s lymphomas is still controversial, there is increasing evidence of the role of this virus in several B-cell lymphoproliferative disorders, whose prototype is mixed cryoglobulinemia. The aim of the present paper was to provide an overview of the biological mechanisms involved in the development of B-cell disorders in the course of chronic hepatitis C virus infection. The link between this virus and non-Hodgkin’s lymphomas is also considered from an epidemiological point of view, and the great regional differences in the prevalence of hepatitis C-associated lymphomas are discussed. Finally, the role of antiviral therapy and suggestions about the most appropriate, currently available, therapeutic approaches are also discussed.

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Published
2011-11-30
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Section
Reviews
Keywords:
Hepatitis C virus - Mixed cryoglobulinemia - Non-Hodgkin’s lymphoma - Interferon - Ribavirin
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How to Cite
Pozzato, G., Zorat, F., Bonetto, S., & Mazzaro, C. (2011). Hepatitis C virus and non-Hodgkin’s lymphoma: biology, epidemiology and therapy. Oncology Reviews, 5(4), 249–260. https://doi.org/10.4081/oncol.2011.40