Molecular pharmacokinetic determinants of anticancer kinase inhibitors in humans

Abstract

This review presents the published data regarding the molecular determinants (drug metabolizing enzymes, drug transporters and orphan nuclear receptors) of approved anticancer kinase inhibitors pharmacokinetics in humans. The clinical impact of these determinants (drug disposition and drug–drug interactions) is also discussed.

Dimensions

Altmetric

PlumX Metrics

Downloads

Download data is not yet available.
Published
2011-06-30
Info
Issue
Section
Reviews
Keywords:
Kinase inhibitor - Cancer - Imatinib - Dasatinib - Nilotinib - Erlotinib - Gefitinib - Sunitinib - Sorafenib - Lapatinib - Pazopanib - Pharmacokinetics - Enzymes - Drug transporters
Statistics
  • Abstract views: 1192

  • FULL TEXT: 191
How to Cite
Scholler, J., & Leveque, D. (2011). Molecular pharmacokinetic determinants of anticancer kinase inhibitors in humans. Oncology Reviews, 5(2), 77-92. https://doi.org/10.4081/oncol.2011.20