Molecular pharmacokinetic determinants of anticancer kinase inhibitors in humans
AbstractThis review presents the published data regarding the molecular determinants (drug metabolizing enzymes, drug transporters and orphan nuclear receptors) of approved anticancer kinase inhibitors pharmacokinetics in humans. The clinical impact of these determinants (drug disposition and drug–drug interactions) is also discussed.
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Copyright (c) 2011 Julie Scholler, Dominique Leveque
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